Effects of angiopeptin on transplant arteriosclerosis in the rat
Identifieur interne : 001280 ( Main/Exploration ); précédent : 001279; suivant : 001281Effects of angiopeptin on transplant arteriosclerosis in the rat
Auteurs : M. L. Akyürek [Suède] ; A. Wanders [Suède] ; M. Aurivillius [Suède] ; E. Larsson [Suède] ; K. Funa [Suède] ; B. C. Fellström [Suède]Source :
- Transplant International [ 0934-0874 ] ; 1995-03-01.
English descriptors
- KwdEn :
- Teeft :
- Abdominal aorta, Allogeneic, Allogeneic grafts, Allograft, Amino acids, Analogue, Angiopeptin, Angiopeptin treatment, Aortic, Arterioscler thromb, Arteriosclerosis, Atherosclerosis, Chronic rejection, Control grafts, Foegh, Graft, Growth factor, Heart lung transplant, Immune cells, Immunohistochemical, Inhibitory effect, Intima, Intimal, Intimal thickness, Lymphocyte, Macrophage, Medial, Medial thickness, Monocyte, Myointimal, Myointimal proliferation, Noninflammatory cells, Nontransplanted portions, Pdgf, Peptide, Preservation solution, Proc, Qint, Receptor, Recipient rats, Smcs, Somatostatin, Somatostatin analogue, Staining intensity, Syngeneic, Syngeneic control grafts, Syngeneic grafts, Transplant, Transplant arteriosclerosis, Transplant atherosclerosis, Transplant proc, Transplantation, Vascular rejection.
Abstract
Abstract: The influence of the somatostatin analogue angiopeptin on transplant arteriosclerosis was investigated using two aortic transplantation rat models. One was characterized by ischemia/reperfusion-induced changes in syngeneic transplants while immunologically induced changes dominated in the other allogeneic model. Angiopeptin, 100 μg/kg per day, was administered continuously until the sacrifice of the rats after 8 weeks. No additional immunosuppression was used in either model. An image analysis system was used to quantify the intimal and medial thicknesses of the grafts. In the syngeneic grafts, the intimal thickness was less than 50% of that of control grafts (P<0.05), but no difference was seen in the allogeneic model. The expression of selected cells, TGF-βs and PDGF and PDGF α-receptors was detected immunohistochemically and displayed a similar picture in control and angiopeptin-treated grafts in both models. We conclude that angiopeptin has no clear immunosuppressive properties but may counteract ischemia-induced transplant arteriosclerosis.
Url:
DOI: 10.1007/BF00344419
Affiliations:
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Funa</name><affiliation wicri:level="1"><country xml:lang="fr">Suède</country><wicri:regionArea>Ludwig Institute for Cancer Research, Biomedical Centre, Box 595, S-751 24, Uppsala</wicri:regionArea><wicri:noRegion>Uppsala</wicri:noRegion></affiliation></author><author><name sortKey="Fellstrom, B C" sort="Fellstrom, B C" uniqKey="Fellstrom B" first="B. C." last="Fellström">B. C. Fellström</name><affiliation wicri:level="1"><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Medicine, University Hospital, S-751 85, Uppsala</wicri:regionArea><wicri:noRegion>Uppsala</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">Transplant International</title><title level="j" type="abbrev">Transpl Int</title><idno type="ISSN">0934-0874</idno><idno type="eISSN">1432-2277</idno><imprint><publisher>Springer-Verlag</publisher><pubPlace>Berlin/Heidelberg</pubPlace><date type="published" when="1995-03-01">1995-03-01</date><biblScope unit="volume">8</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="103">103</biblScope><biblScope unit="page" to="110">110</biblScope></imprint><idno type="ISSN">0934-0874</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0934-0874</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Angiopeptin, arteriosclerosis, rat</term><term>Aorta transplantation, arteriosclerosis</term><term>Arteriosclerosis, angiopeptin, rat</term></keywords><keywords scheme="Teeft" xml:lang="en"><term>Abdominal aorta</term><term>Allogeneic</term><term>Allogeneic grafts</term><term>Allograft</term><term>Amino acids</term><term>Analogue</term><term>Angiopeptin</term><term>Angiopeptin treatment</term><term>Aortic</term><term>Arterioscler thromb</term><term>Arteriosclerosis</term><term>Atherosclerosis</term><term>Chronic rejection</term><term>Control grafts</term><term>Foegh</term><term>Graft</term><term>Growth factor</term><term>Heart lung transplant</term><term>Immune cells</term><term>Immunohistochemical</term><term>Inhibitory effect</term><term>Intima</term><term>Intimal</term><term>Intimal thickness</term><term>Lymphocyte</term><term>Macrophage</term><term>Medial</term><term>Medial thickness</term><term>Monocyte</term><term>Myointimal</term><term>Myointimal proliferation</term><term>Noninflammatory cells</term><term>Nontransplanted portions</term><term>Pdgf</term><term>Peptide</term><term>Preservation solution</term><term>Proc</term><term>Qint</term><term>Receptor</term><term>Recipient rats</term><term>Smcs</term><term>Somatostatin</term><term>Somatostatin analogue</term><term>Staining intensity</term><term>Syngeneic</term><term>Syngeneic control grafts</term><term>Syngeneic grafts</term><term>Transplant</term><term>Transplant arteriosclerosis</term><term>Transplant atherosclerosis</term><term>Transplant proc</term><term>Transplantation</term><term>Vascular rejection</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: The influence of the somatostatin analogue angiopeptin on transplant arteriosclerosis was investigated using two aortic transplantation rat models. One was characterized by ischemia/reperfusion-induced changes in syngeneic transplants while immunologically induced changes dominated in the other allogeneic model. Angiopeptin, 100 μg/kg per day, was administered continuously until the sacrifice of the rats after 8 weeks. No additional immunosuppression was used in either model. An image analysis system was used to quantify the intimal and medial thicknesses of the grafts. In the syngeneic grafts, the intimal thickness was less than 50% of that of control grafts (P<0.05), but no difference was seen in the allogeneic model. The expression of selected cells, TGF-βs and PDGF and PDGF α-receptors was detected immunohistochemically and displayed a similar picture in control and angiopeptin-treated grafts in both models. We conclude that angiopeptin has no clear immunosuppressive properties but may counteract ischemia-induced transplant arteriosclerosis.</div></front></TEI><affiliations><list><country><li>Suède</li></country></list><tree><country name="Suède"><noRegion><name sortKey="Akyurek, M L" sort="Akyurek, M L" uniqKey="Akyurek M" first="M. L." last="Akyürek">M. L. Akyürek</name></noRegion><name sortKey="Aurivillius, M" sort="Aurivillius, M" uniqKey="Aurivillius M" first="M." last="Aurivillius">M. Aurivillius</name><name sortKey="Fellstrom, B C" sort="Fellstrom, B C" uniqKey="Fellstrom B" first="B. C." last="Fellström">B. C. Fellström</name><name sortKey="Funa, K" sort="Funa, K" uniqKey="Funa K" first="K." last="Funa">K. Funa</name><name sortKey="Larsson, E" sort="Larsson, E" uniqKey="Larsson E" first="E." last="Larsson">E. Larsson</name><name sortKey="Wanders, A" sort="Wanders, A" uniqKey="Wanders A" first="A." last="Wanders">A. 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